Effect of Moringa oleifera on some physiological parameters in diclofenac treated rats

Mohamed, Maha G.; Shaheen, Eman M. S.; Abd-El Maksoud, Marwa A. E.; Seddek, Mohamed N.

doi:10.21608/jbes.2024.374445

Effect of Moringa oleifera on some physiological parameters in diclofenac treated rats

Document Type : Original Article

Authors

Zoology Department, Faculty of Science, Benha University, Benha, Egypt.

10.21608/jbes.2024.374445

Abstract

The present work aims to study the potential effect of aqueous leaves extract Moringa
oleifera (MO) on male albino rats treated orally with diclofenac sodium (DcNa). Fortyfive male albino rats were used and randomly divided into 5 groups as follows: group I
"normal group", group II "DcNa group", group III "MO group", group IV "DcNa then
MO group" and group V "MO then DcNa group". Treatment with DcNa showed a
significant decrease in body weight while caused significant increases in relative organs
weight (liver, kidney, spleen and brain). Moringa oleifera caused a significant increase
in body weight while showed non-significant decreases in relative organs weight (liver,
kidney and spleen). DcNa exhibited significant decreases in WBCs count, lymphocytes
% and neutrophil % while caused a significant increase in monocyte %. Also, there were
non-significant increase and decrease in eosinophil % and basophil % respectively.
Treatment with MO showed non-significant increases in white blood cell count,
monocyte % and neutrophil % while showed non-significant decrease in lymphocyte %.
Eosinophil % and basophil % were increased significantly. Administration of DcNa
caused significant decreases in serum total protein, albumin and globulin levels.
Treatment with Moringa oleifera showed a significant increase in serum albumin level
while showed non-significant increases in serum total protein and globulin levels.
The present study suggests that Moringa oleifera is useful in maintaining the harmful
effect of diclofenac sodium in male albino rats.

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