Synthesis of new imidazolone derivatives and evaluated their biological activities

Document Type : Original Article

Authors

Chemistry Department, Faculty of Science,Benha University

Abstract

Some novel imidazolone derivatives were synthesized in excellent yields and evaluated for their antifungal activities. The structures of the prepared compounds were proved by IR, 1H-NMR, Mass spectra. The antifungal activities of imidazolone derivatives were evaluated by the agar well diffusion method. From the result of biological activity 2-((4-(4-chlorobenzylidene)-5-oxo-4,5-dihydrooxazol-2-yl)methyl)isoindoline-1,3-dione (1) showed high activity against Aspergillus flavus and Aspergillus ochrachous.