Potentiometric determination of alfuzosin hydrochloride in pharmaceutical preparations and biological fluids using modified carbon paste electrodes

Hasseb, Alaa A.A.M.; Mohamed, Gehad G.; Elashery, Sally E.A.

doi:10.21608/jbes.2019.371128

Potentiometric determination of alfuzosin hydrochloride in pharmaceutical preparations and biological fluids using modified carbon paste electrodes

Document Type : Original Article

Authors

¹ Chemistry Department, Faculty of Science, Cairo University, Giza, 12613, Egypt

² Chemistry Department, Faculty of Science, Cairo University, Giza, 12613, Egypt Egypt Nanotechnology Center, Cairo University, El-Sheikh Zayed, 6th October City, Giza 12588, Egypt

10.21608/jbes.2019.371128

Abstract

The performance characteristic of sensitive modified carbon paste electrodes (MCPE) was suggested for alfuzosin
hydrochloride (ALFHC) determination in its pure, pharmaceutical preparations and biological samples. Various
experimental conditions namely materials types that used to prepare the working electrodes (plasticizer), pH, titrant,
interfering ions and life time were studied. MCPE gave suitable response to ALFHC over pH range 2.9 – 6.7 for
electrode (I) and 2.9-7.7 for electrode (II). ALFHC selectivity relative to different potential interfering species was
reported. The MCPEs were used over a period of 3 months with a good reproducibility. The studied sensors were
successfully applied to determine ALFHC in its pharmaceutical preparations and biological fluid samples. The obtained
results are compared with the official method.

Keywords