A validated micro-sensitive stability-indicating adsorptive stripping voltammetric determination of Alverine citrate utilizing G

Document Type : Original Article

Authors

1 National Organization for Drug Control and Research (NODCAR) Pyramids Ave., P. O. B 29 Cairo, Egypt.

2 Chemistry Department, Faculty of Science, Benha University, Benha, Egypt

Abstract

An inexpensive stability indicating anodic voltammetric method for rapid determination of ALV has been developed and
validated. The method was based on the enhancement of voltammetric response at a nano zinc oxide and graphene oxide
modified electrode (ZGE). Square wave voltammetry (SWV) method was developed for quantification of drug in BR buffer
solution (pH 6.0) at ZGE. The ZGE displayed very good voltammetric behavior with significant enhancement of the peak
current compared to carbon paste electrode (CPE). Stress stability studies were performed using 0.1 M of HCl and NaOH. Mass
and infrared spectroscopy were used for identification of degradants and their pathways were illustrated. Under optimal
conditions, the peak currents showed a linear dependence with drug concentrations. The achieved limits of detection (LOD)
were 0.640 and 1.940 for first peak and second peak respectively of ALV oxidation waves. The developed voltammetric method
was successfully applied for direct determination of ALV in drug substances, pharmaceutical vials and in presence of either
their corresponding hydrolytic, oxidative-degradants or interfering substances with no potential interferences. The SWV
voltammograms were highly advantageous and applicable in QC laboratories for rapid, selective micro-determination of ALV.
Journal of Basic and Environmental Sciences
Volume 5, Issue 2
April 2018
Pages 149-154

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