Chemical and Bioactivity Studies on Salvia Africana-Lutea: Cytotoxicity and Apoptosis Induction by Abietane Diterpenes Isolated from Salvia Africana-Lutea

Document Type : Original Article

Authors

1 Professor of Organic Chemistry, Benha University, Egypt

2 Professor of Chemistry, National Research Centre, Cairo, Egypt.

3 Professor of Marine, National Institute, Egypt.

4 B.Sc. Chemistry Department, Benha University, Egypt

Abstract

Re-investigation of the phytochemical constituents of Salvia africana-lutea L. methanolc extract, led to the purification 
and identification of six abietane diterpene (7 -methoxyrosmanol (1), rosmadial (2), rosmanol (3), carnosol (4), 
epiisorosmanol (5), epirosmanol (6)) and rosmarinic acid methyl ester (7). The compounds 1 and 3-5 showed significant 
anti-proliferative effect on HT-29 and MCF-7 cells, additionally, 7 -methoxyrosmanal (1) found to induce apoptosis in 
colorectal adenocarcinoma cells. The apoptotic pathway is characterized by the activation of caspases cascade (viz 
caspase 9) which climaxed in caspase-3 activation.
Journal of Basic and Environmental Sciences
Volume 5, Issue 1
January 2018
Pages 72-79

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